Chemical resolution of secondary (±)-alcohols
نویسندگان
چکیده
منابع مشابه
Double Immobilized Lipase for the Kinetic Resolution of Secondary Alcohols
Sol-gel immobilization of enzymes, which can improve considerably their properties, is now one of the most used techniques. By deposition of the entrapped lipase on a solid support, a new and improved biocatalyst was obtained, which can be used with excellent results in acylation reactions. In this paper, lipase B from Candida antarctica was double immobilized on different adsorbents. These bio...
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The use of in situ generated (NHC)-Ni catalytic species (NHC = N-heterocyclic carbene) allows for the synthesis, in short reaction times, of a variety of tertiary alcohols from secondary alcohols through a domino oxidation-addition protocol.
متن کاملNegative chemical ionization of alcohols.
Reactions of the oxygen radical anion at low pressure (ICR conditions) with aliphatic alcohols are seen to give a limited number of product anions which allows for unambiguous determination of the structure of the neutral. The reactions of OH- are also investigated and mechanisms of reactions are discussed. Analytical application of NCI is also considered. OH- negative chemical ionization mass ...
متن کاملTheoretical prediction of selectivity in kinetic resolution of secondary alcohols catalyzed by chiral DMAP derivatives.
The mechanism of esterification of the secondary alcohol 1-(1-naphthyl)ethanol 9 by isobutyric anhydride catalyzed by 4-pyrrolidinopyridine (PPY, 11) and a series of single enantiomer atropisomeric 4-dialkylaminopyridines 8a-g has been studied computationally at the B3LYP/6-311+G(d,p)//B3LYP/6-31G(d) level. Comparison of the levels of enantioselectivity predicted computationally with the result...
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An (S)-selective dynamic kinetic resolution of secondary alcohols, employing a mutated variant of Candida antarctica lipase B (CalB) gave products in 84-88% yield and in 90-97% ee.
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ژورنال
عنوان ژورنال: Australian Journal of Chemistry
سال: 1966
ISSN: 0004-9425
DOI: 10.1071/ch9661533